Squamous cell carcinoma of the right renal pelvis in a 46-years-old with long history of right pyelolithiasis. A case report and review of literature
Squamous cell carcinoma of the kidney is a rare malignancy of the upper urothelium usually seen at advanced stage due to delay in diagnosis and or presentation. Mostly seen in patients with history of untreated chronic urolithiasis, chronic renal infection or analgesic abuse. A 46-years-old man who presented with right recurrent loin pain that radiates to the right groin of 10 years duration which worsened 2 weeks prior to presentation, he had history of recent haematuria, right loin pain, significant weight lost with associated history of untreated right renal calculi. General examination was not remarkable, ultrasound scan revealed a huge right renal mass with calculi. Intravenous urogram showed a non-functioning right kidney. Right radical nephrectomy was done, cut surface showed replacement of the renal parenchyma with greyish white tumour with stones in some blind calyxes. Histology revealed moderately differentiated squamous cell carcinoma of the right kidney. We report a case of moderately differentiated squamous cell carcinoma of the right kidney in a patient with a long history of untreated renal calculi. High index of suspicion for malignancy should be kept when seeing patients with long history of untreated renal calculi.
Li MK, Cheung WL. Squamous cell carcinoma of the renal pelvis. J Urol 1987;138:269-71.
Bandypadhyoy R, Biswas S, Nag D, Ghosh AK. Squamous cell carcinoma of the renal pelvis presenting as hydronephrosis. J Can Res Ther 2010;6:537-9. DOI: https://doi.org/10.4103/0973-1482.77060
Holmang S, Lele SM, Johansson SL. Squamous cell carcinoma of the renal pelvis and ureter: incidence, symptoms, treatment and outcome. J Urol 2007;178:51-6. DOI: https://doi.org/10.1016/j.juro.2007.03.033
Jain A, Mittal D, Solanki R, et al. incidentally detected squamous cell carcinoma of the renal pelvis in patients with staghorn calculi: a case series with review of literature. ISRN Oncol 2011;2011:620574.
Karabulut A, Emir L, Gonultas M, et al. squamous cell carcinoma located in the renal caliceal system: A case report and review of the literature. Turk J Cancer 2002;32:20-4.
Mardi K, Kaushal V. Rare coexistence of keratinizing squamous cell carcinoma with xanthogranulomatous pyelonephritis in the same kidney: report of two cases. J Cancer Res Ther 2010;6:339-41. DOI: https://doi.org/10.4103/0973-1482.73351
Busby JE, Brown GA, Tamboli P, et al. Upper urinary tract tumors with nontransitional histology: A single-center experience. Urology 2006;67:518-23. DOI: https://doi.org/10.1016/j.urology.2005.09.010
Blacher EJ, Johnson DE, Abdul-Karim FW, Ayala AG. Squamous cell carcinoma of renal pelvis. Urology 1985;25:124-6.
Latham HS, Kay S. Malignant tumors of the renal pelvis. Surg Gynecol Obstet 1974;138:613-22.
Utz DC, Mc Donalt JR. Squamous cell carcinoma of the kidney. J Urol 1957;78:540-52. DOI: https://doi.org/10.1016/S0022-5347(17)66475-9
Li MK, Cheung WL. Squamous cell carcinoma of the renal pelvis. J Urol 1987;138:269-71. DOI: https://doi.org/10.1016/S0022-5347(17)43116-8
Blacher EJ, Johnson DE, Abdul-Karim FW, et al. Squamous cell carcinoma of renal pelvis. Urology 1985;25:124-6. DOI: https://doi.org/10.1016/0090-4295(85)90526-6
Talwar N, Dargan P, Arora MP, et al. Primary squamous cell carcinoma of the renal pelvis masquerading as pyonephrosis: A case report. Indian J Pathol Microbiol 2006;49:418-20.
Cadeddu JA, Jarrett TW. Hypercalcemia associated with squamous cell carcinoma of the renal pelvis. J Urol 1998;160:1798. DOI: https://doi.org/10.1097/00005392-199811000-00054
Er O, Coskun HS, Altinbas M, et al. Rapidly relapsing squamous cell carcinoma of the renal pelvis associated with paraneoplastic syndromes of leukocytosis, thrombocytosis and hypercalcemia. Urol Int 2001;67:175-7. DOI: https://doi.org/10.1159/000050980
Lee TY, Ko SF, Wan YL, et al. Renal squamous cell carcinoma: CT findings and clinical significance. Abdom Imaging 1998;23:203-8. DOI: https://doi.org/10.1007/s002619900324
Jain A, Mittal D, Jindal A, et al. Incidentally detected squamous cell carcinoma of renal pelvis in patients with staghorn calculi: Case series with review of the literature. ISRN Oncol 2011;2011:620574. DOI: https://doi.org/10.5402/2011/620574
Nativ O, Reiman HM, Lieber MM, Zincke H. Treatment of primary squamous cell carcinoma of the upper urinary tract. Cancer 1991;68:2575-8. DOI: https://doi.org/10.1002/1097-0142(19911215)68:12<2575::AID-CNCR2820681208>3.0.CO;2-V
Kose F, Bal N, Ozyilkan O. Squamous cell carcinoma of the renal pelvis. Med Oncol 2009;26:103-4. DOI: https://doi.org/10.1007/s12032-008-9089-4
Maclennan GT, Cheng L. Renal pelvis and ureter. In: Maclennan GT, Cheng L, editors. Atlas of genitourinary pathology. New York, USA: Springer; 2011: pp. 123-40. DOI: https://doi.org/10.1007/978-1-84882-395-2_3
Reuter VE. The urothelial tract: Renal pelvis, ureter, urinary bladder and urethra. In: Mills SE, Carter D, Greenson JK, et al. (eds). Sternberg’s Diagnostic Surgical Pathology. 4th ed. Philadelphia: Lippincott Williams and Wilkins; 2004: pp. 2058-9.
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