Thyroid peroxidase antibody levels among human immunodeficiency virus infected patients in Kano, North-Western Nigeria


Submitted: May 16, 2018
Accepted: June 9, 2018
Published: July 10, 2018
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Authors

  • Isah A. Yahaya Department of Chemical Pathology and Immunology, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.
  • Sherifah U. Sherif Department of Chemical Pathology and Immunology, Aminu Kano Teaching Hospital, Kano, Nigeria.
  • Kabiru Abdulsalam Department of Chemical Pathology and Immunology, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria.

Autoimmunity plays a role in the development of thyroid dysfunction in human immunodeficiency virus (HIV) infected patients. This study assessed the serum levels of thyroid peroxidise antibody (TPO-Ab) in relation to the various forms of thyroid dysfunction in HIV patients in Kano. Free tri-iodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH) and TPO-Ab were measured using Chemiluminescent immunoassay(CLIA) on the serum of 70 HIV sero-positive patients on Highly Active Antiretroviral Therapy (HAART, as Group I), 70 HAART naïve HIV sero-positive patients (Group II) and 70 apparently healthy HIV negative controls (Group III). The prevalence of thyroid dysfunctions were 55.7%, 42.9% and 2.8% among groups I, II and III respectively. TPO-Ab was elevated in 1 (1.43%) HIV positive patient on HAART, Group I, that also had subclinical hyperthyroidism. Four participants (5.7%) among group III were found to have elevated anti-TPO levels. Thyroid dysfunction was more common among HIV-positive than HIV-negative participants. Thyroid dysfunction among HIV patients was mainly non-autoimmune in origin. However, thyroid autoimmunity appears to play a little role in the development of hyperthyroidism in HIV patients.


Yahaya, Isah A., Sherifah U. Sherif, and Kabiru Abdulsalam. 2018. “Thyroid Peroxidase Antibody Levels Among Human Immunodeficiency Virus Infected Patients in Kano, North-Western Nigeria”. Annals of African Medical Research 1 (1). https://doi.org/10.4081/aamr.2018.15.

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