A huge abdomino-pelvis tumour in a prepubertal girl: A case report of dysgerminoma infiltrating both ovaries and uterus in an 11-year-old girl in Maiduguri
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Dysgerminoma is one of the rare highly malignant ovarian germ cell tumour. It originate from undifferentiated germ cells that are similar to primordial germ cells, and it is identical to testicular seminoma in males. Despite the tumour being malignant, prognosis is excellent with surgery and adjuvant chemotherapy, with promising results concerning future fertility. In this case, we report an 11-year-old girl with abdominal swelling for 7 years. She had gross abdominal distension, with a huge palpable mass. Abdominopelvic ultrasound scan showed a huge heterogeneous mass measured 9.8 cm x 15.7 cm and computed tomography showed a huge lobulated mass measured 19.2 cm x 19.0 cm x 16.3 cm. Exploratory laparotomy and excision of the mass was done. Ovarian dysgerminoma are uncommon in prepubertal girls. Prognosis depends on the stage at presentation and histology. Multidisciplinary management with a Gynaecologists and Oncologists with joint decision on the need to maintain the child’s developmental and reproductive potential as much as possible should aimed at.
Gupta B, Guleria K, Suneja A, et al. Adolescent ovarian masses: A retrospective analysis. J Obstet Gynaecol 2016;36:515-7. DOI: https://doi.org/10.3109/01443615.2015.1103721
Al Jama FE, Al Ghamdi AA, Gasim T, et al. Ovarian tumours in children and adolescents - a clinical study of 52 patients in a university hospital. J Pediatr Adolesc Gynecol 2011;24:25-8. DOI: https://doi.org/10.1016/j.jpag.2010.06.005
Cheng L, Roth LM, Zhang S et al. KIT gene mutation and amplification in dysgerminoma of the ovary. Cancer 2011;117:2096–103. DOI: https://doi.org/10.1002/cncr.25794
Merino MJ, Jaffe G. Age contrast in ovarian pathology. Cancer 1993;71:537‑44. DOI: https://doi.org/10.1002/cncr.2820710208
Heo SH, Kim JW, Shin SS, et al. Review of ovarian tumours in children and adolescents: Radiologic‑pathologic correlation. Radiographics 2014;34:2039‑55. DOI: https://doi.org/10.1148/rg.347130144
Okunade KS, Yakubu CI, Osuji N, Salako O. A rare case of ovarian dysgerminoma in a 6-year old child in Lagos: A case report. Trop J Obstet Gynaecol 2017;34:246-9. DOI: https://doi.org/10.4103/TJOG.TJOG_49_17
Ehren IM, Mahour GH, Isaac H. Benign and malignant ovarian tumours in children and adolescents: A review of cases. Am J Surg 1984;147:339 DOI: https://doi.org/10.1016/0002-9610(84)90163-6
von Allmen D. Malignant lesions of the ovary in childhood. Semin Pediatr Surg 2005;14:100‑5. DOI: https://doi.org/10.1053/j.sempedsurg.2005.01.005
Vidal IS, Soares LS, Gurgel KB, et al. Hot Flushes in a 15-Year-Old Girl Post Treatment of Bilateral Ovarian Dysgerminoma: A Case Report. Obstet Gynecol Cases Rev 2018;5:120.
Ajani MA, Aramide KO, Ajani TA, et al. Childhood ovarian neoplasms in Ibadan, South‑Western Nigeria. Niger Med J 2016;57:164‑6. DOI: https://doi.org/10.4103/0300-1652.184061
Roberts OA, Oranye BC. Ovarian dysgerminoma in an adolescent: A case report. Afr J Med Sci 2013;42:197‑200.
Breen J, Denehy T, Taylor RR. Pediatric Ovarian Malignancies. Glob Libr Women's Med 2008; doi 10.3843/GLOWM.10251.
Vicus D, Beiner ME, Klachook S, et al. Pure dysgerminoma of the ovary 35 years on: a single institutional experience. Gynaecol Oncol 2010;117:23–6. DOI: https://doi.org/10.1016/j.ygyno.2009.12.024
Biswajit D, Patil CN, Sagar TG. Clinical presentation and outcome of paediatric ovarian germ cell tumour: a study of 40 patients. J Paediatr Haematol Oncol 2010;32:54–6. DOI: https://doi.org/10.1097/MPH.0b013e3181c5ad9b
Hyseni N, Llullaku S, Jashari H et al. Advanced ovarian dysgerminoma infiltrating both ovaries and uterus in a 7-year-old girl. Case Rep Oncol Med 2014;2014:910852. DOI: https://doi.org/10.1155/2014/910852
Nishio S, Ushijima K, Fukui A, et al. Fertility-preserving treatment for patients with malignant germ cell tumours of the ovary. J Obst Gynaecol Res 2006;32:416–21. DOI: https://doi.org/10.1111/j.1447-0756.2006.00417.x
Kumar S, Shah JP, Bryant CS, et al. The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumours of the ovary. Gynecol Oncol 2008;110:125–32. DOI: https://doi.org/10.1016/j.ygyno.2008.04.022
Andres MM, Costa E, Canete A, et al. Solid ovarian tumours in childhood: a 35-year review in a single institution. Clin Transl Oncol 2010;12:287–91. DOI: https://doi.org/10.1007/s12094-010-0505-9
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.