Thyroid hormones profile of patients with type 2 diabetes mellitus in Kano, Nigeria


Published: October 5, 2020
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Diabetes mellitus (DM) and thyroid disease are the two most common endocrine disorders in the general population. Several Studies have shown that thyroid dysfunction is common in patients with DM, and thyroid dysfunction have been found to have a considerable impact on the glycaemic control and often increases the risk of development of long-term complications in patients with diabetes mellitus. This study determined the prevalence of thyroid dysfunction in patients with type 2 DM in Kano, North-Western Nigeria. The study was a descriptive cross-sectional study conducted on 250 participants made up of 130 patients with type 2 DM and 120 apparently healthy non-diabetic controls. Questionnaires were used to collect information on bio data, medical history, duration of diagnosis of diabetes and type of treatment. Also, blood samples of the participants were collected and analyzed for fasting plasma glucose, fT3, fT4, and TSH. The results were interpreted using American Thyroid Associations’ criteria and the data was analyzed using the statistical software package, STATA version 20. Two hundred and thirty-four (93.6%) of the participants were euthyroid while sixteen (6.4%) were found to have various forms of thyroid dysfunction. The prevalence of thyroid dysfunction was 10% and 2.5% among type 2 diabetics and controls respectively. Among the type 2 DM patients with thyroid dysfunction, 38.5% had hypothyroidism. Thyroid dysfunction was found to be commoner among type 2 DM patients than non-diabetic individuals with hypothyroidism being the commonest disorder.


Nicholas A. Type 2 Diabetes Mellitus and Thyroid Dysfunction. African Journal of Diabetes Medicine 2015; 22 (2): 21-23.

Kumar P, Clark M (Editors). Kumar & Clark’s Clinical Medicine. 7th edition. Spain: Saunders Elsevier; c2009. P. 982-993, 1029-1059.

World Health Organization. Global Reports on Diabetes 2016: WHO; Geneva, Switzerland, 2016.

International Diabetes Federation. International Diabetes Federation Africa Region. www.idf.org/membership/afr/nigeria.

Wu P. Thyroid Disease and Diabetes. Clinical Diabetes 2000,18 (1):1-4.

Cardoso C, Ohwovoriole AE, Kuku SF. A Study of Thyroid Function and Prevalence of Thyroid Autoantibodies in an African Diabetic Population. Journal of Diabetes and its Complications 1995; 9(1): 37-41. DOI: https://doi.org/10.1016/1056-8727(93)00022-3

Ghazali SM, Abbiyesuku FM. Thyroid Dysfunction in Type 2 Diabetes seen at University College Hospital, Ibadan, Nigeria. Nigerian Journal of Physiological Science 2010; 25: 173-179.

Ravishankar SN, Champakamalini, Venkatesh, Mohsin. A Prospective Study of Thyroid Dysfunction in Patients with Type 2 Diabetes in General Population. imedPub Journal 2013; 5(1:2): 1-9.

Udiong CEJ, Udoh AE, Etukudoh ME. Evaluation of Thyroid Function in Diabetes Mellitus in Calabar, Nigeria. Indian Journal of Clinical Biochemistry 2007; 22 (2): 74-78.

Dias CM, Nogueira P, Rosa AN, De-Sa JV, Gouvea MF, Mannho-Falcos CM. Total Cholesterol and High Density Cholesterol in Patients with Insulin Dependent Diabetes Mellitus. Acta Medica 1995; 8(11): 619-628.

Murray RK, Granner DK, Mayes PA, Rodwell VW. Harper’s Biochemistry. 25th edition. London: Prentice-Hall International Inc; 2000. P. 533-538.

Gabriela B. Diabetes and Thyroid Disorders. British Journal of Diabetes and Vascular Disease 2010; 10(4): 172-177. DOI: https://doi.org/10.1177/1474651410371321

Radaideh AR, El-Khateeb M, Bateiha AM, Nasser AS, Ajlouni KM. Thyroid Function and Thyroid Autoimmunity in Patients with Type 1 Diabetes Mellitus. Saudi Medical Journal 2003; 24(4): 352-355.

Udiong CEJ, Udoh AE, Etukudoh ME. Evaluation of Thyroid Function in Diabetes Mellitus in Calabar, Nigeria. Indian Journal of Clinical Biochemistry 2007; 22 (2): 74-78. DOI: https://doi.org/10.1007/BF02913318

Vigersky RA, Filmore-Nassar A, Glass AR. Thyrotropin Suppression by Metformin. Journal of Clinical Endocrinology and Metabolism 2006; 91(1): 225-227. DOI: https://doi.org/10.1210/jc.2005-1210

Cappelli C, Rotondi M, Pirola. Thyrotropin Level in Diabetic Patients on Metformin Treatment. European Journal of Endocrinology 2012; 167(2): 261-265. DOI: https://doi.org/10.1530/EJE-12-0225

Ravishankar SN, Champakamalini, Venkatesh, Mohsin. A Prospective Study of Thyroid Dysfunction in Patients with Type 2 Diabetes in General Population. imedPub Journal 2013; 5(1:2): 1-9.

Surks MI, Ortiz E, Daniels GH. Subclinical Thyroid Disease: Scientific Review and Guidelines for Diagnosis and Management. JAMA 2004; 291: 228-238. DOI: https://doi.org/10.1001/jama.291.2.228

Becker DV, Bigos ST, Gaitan E, Morris III JC, Rallison ML, Spencer CA, et al. Optimal use of Blood Tests for Assessment of Thyroid Function. JAMA 1993; 3(4): 269-273.

Demer LM, Spencer CA. Laboratory Medicine Practice. Laboratory Support for the Diagnoses and Monitoring of Thyroid Disease. Clinical Endocrinology 2003; 58:138-140. DOI: https://doi.org/10.1046/j.1365-2265.2003.01681.x

Baloch Z, Carayon P, Conte-Davolx B, Demers LM, Feldt-Rasmussen U, Henry IF, et al. Laboratory Medicine Practice Guidelines. Laboratory Support for the Diagnosis and Monitoring of Thyroid Disease. Thyroid 2003; 13: 3-126. DOI: https://doi.org/10.1089/105072503321086962

STATA statistical package version 13 (stata corp., College Station, Texas USA) (2016)

Haruna R, Attah YE, Purity NO. Understanding and Overcoming the Challenges of Youth Unemployment in Nigeria. Review of Public Administration and Management 2014; 3(5): 206-214

Smithson MJ. Screening for thyroid dysfunction in a community population of diabetic patients. Diabet Med. 1998; 15(2): 148–150. DOI: https://doi.org/10.1002/(SICI)1096-9136(199802)15:2<148::AID-DIA540>3.0.CO;2-H

Radaideh ARM, Nusier MK, Amari FL. Thyroid Dysfunction in Patients with Type 2 Diabetes Mellitus in Jordan. Saudi Medical Journal 2004; 25(8): 1046-1050.

Akbar DH, Ahmed MM, Al-Mughales J. Thyroid Dysfunction and Thyroid Autoimmunity in Saudi Type 2 Diabetics. Acta Diabetologica 2006; 43(1): 14-18. DOI: https://doi.org/10.1007/s00592-006-0204-8

Perros P, McCrimmon RJ, Shaw G, Frier BM. Frequency of Thyroid Dysfunction in Diabetic Patients: Value of Annual Screening. Diabetic Medicine 1995; 12(7): 622-627. DOI: https://doi.org/10.1111/j.1464-5491.1995.tb00553.x

Roche Diagnostics Ltd. Electro-chemiluminescence immunoassay (ECLIA) for the in vitro quantitative determination of free triodothyronine in human serum and plasma. T3 FactSheet. CH-6343 Rotkreuz, Switzerland. c2011 Roche.

Roche Diagnostics Ltd. Electro-chemiluminescence immunoassay (ECLIA) for the in vitro quantitative determination of free thyroxine in human serum and plasma. T4 FactSheet. CH-6343 Rotkreuz, Switzerland. c2011 Roche.

Elecsys TSH-Roche Diagnostics. Electro-chemiluminescence immunoassay (ECLIA) for the in vitro quantitative determination of thyrotropin in human serum and plasma. TSH FactSheet. CH-6343 Rotkreuz, Switzerland. c2011 Roche.

Chen HS, Wu TE, Jap TS. Subclinical Hypothyroidism is a Risk Factor for Nephropathy and Cardiovascular Disease in Type 2 Diabetic Patients. Diabetic Medicine 2007; 24: 1336-1344. DOI: https://doi.org/10.1111/j.1464-5491.2007.02270.x

Yang JK, Liu W, Shi J, Li YB. An Association between Subclinical Hypothyroidism and Sight-Threatening Diabetic Retinopathy in Type 2 Diabetic Patients. Diabetic Care 2010; 33:1018-1020. DOI: https://doi.org/10.2337/dc09-1784

Swamy RM, Kumar N, Srinivas K, Manjunath GN, Prasad BDS. Evaluation of hypothyroidism as a complication of type 2 diabetes mellitus. Biomedical Research 2012; 23(2):170–172.

Dias CM, Nogueira P, Rosa AN, De-Sa JV, Gouvea MF, Mannho-Falcos CM. Total Cholesterol and High Density Cholesterol in Patients with Insulin Dependent Diabetes Mellitus. Acta Medica 1995; 8(11): 619-628.

Murray RK, Granner DK, Mayes PA, Rodwell VW. Harper’s Biochemistry. 25th edition. London: Prentice-Hall International Inc; 2000. P. 533-538.

Ravishankar SN, Champakamalini, Venkatesh, Mohsin. A Prospective Study of Thyroid Dysfunction in Patients with Type 2 Diabetes in General Population. imedPub Journal 2013; 5(1:2): 1-9.

Gursoy NT, Tuncel E. The relationship between the glycemic control and the hypothalamus-pituitary-thyroid axis in diabetic patients. Turkish Journal of Endocrinology and Metabolism 1999; 4: 163–168

Hage M, Zantout MS, Azar ST. Thyroid Disorders and Diabetes Mellitus. Journal of Thyroid Research 2011; 2011: 439463. DOI: https://doi.org/10.4061/2011/439463

Zainab Abubakar , Mustapha, Kabiru Abdulsalam, and Isah A. Yahaya. 2020. “Thyroid Hormones Profile of Patients With Type 2 Diabetes Mellitus in Kano, Nigeria”. Annals of African Medical Research 3 (1). https://doi.org/10.4081/aamr.2020.112.

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